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. 2021 Jun 24;19:186. doi: 10.1186/s12957-021-02299-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Representative images of staining of CD163+ TAMs. Tumor tissue with high TAM infiltration are shown at 200× (A) and 400× (B) magnification, and tumor tissue with low TAM infiltration are shown at 200× (C) and 400× (D). E Graphs stratifying patients by CD163+ TAM levels in 209 CRC patients based on a median value of 115