Table 2.
Demographics
| No-EOS | EOS | p | |
|---|---|---|---|
| N = 166 | 135 | 31 | |
| Male, a) | 54 (40) | 15 (48) | 0.514 |
| Gestational Age Weeks (wk + d), b) | 29 + 2 (± 2 + 2) | 27 + 6 (± 2 + 0) | 0.001 |
| Birth weight g, b) | 1160.56 (± 267.62) | 974.97 (± 276.40) | 0.001 |
| Umbilical artery pH, b) | 7.30 (± 0.09) | 7.29 (± 0.08) | 0.811 |
| Apgar 1′/5′/10′, c) | 7 / 8 / 8 | 7 / 8 / 8 | 0.125 / 0.041 / 0.057 |
| Apgar 1′/5′/10′ c) | (1; 6–8; 9 / 3; 7–8; 9 / 5; 8–9 10) | (4; 6–8; 8 / 3; 7–8; 9 / 3; 8–8; 9) | |
| CRIB-Score, c) | 1 (0 / 0–3 / 11) | 3 (0 / 1.75–5.25 / 12) | 0.001 |
| Highest Bilirubin, μmol/l, b) | 143.85 (± 23.44) | 148.74 (± 62.31) | 0.472 |
| Antenatal steroids 1 dose / 2 doses, a) | 72 (53) / 35 (26) | 18 (58) / 11 (35) | 0.633 / 0.284 |
| Ceaseraen delivery, a) | 121 (90) | 30 (97) | 0.366 |
| Patent ductus arteriosus, d) | 36 (27) | 10 (32) | 0.830 |
| BPD, f) | 6 (4) | 6 (19) | 0.011 |
| Retinopathia neonatorum ≥3, d) | 2 (1) | 0 | 0.999 |
| Intraventricular haemorrhage ≥3, d) | 4 (3) | 2 (6) | 0.312 |
| Periventricular leukomalacia, d) | 1 (1) | 1 (3) | 0.340 |
| Parental Education Score 1/2 d); 3/4 a); a) | 1 (1) / 7 (5) / 76 (56) / 47 (35) | 0 / 2 (6) / 17 (55) / 10 (32) | 0.999 / 0.667 / 0.999 / 0.999 |
| Max CrP 72 h postnatal, c) | 0.62 (0 / 0–1.525 / 8.37) | 14.36 (5.37 / 9.5–28.07 / 68.45) | 0.000 |
| Leukocytes in first CBC, ×109, b) | 9.9 (±5.71) | 10.22 (±11.09) | 0.824 |
| Leukopenia a) | 9 (7) | 10 (32) | 0.000 |
| Leukocytosis d) | 4 (3) | 3 (10) | 0.122 |
| Combinded abnormal WBC a) | 13 (10) | 13 (42) | 0.000 |
| Thrombocytes in first CBC, × 109, b) | 181.8 (±69.7) | 173.4 (±71.7) | 0.547 |
| Thrombocytopenia, a) | 40 (30 | 14 (45) | 0.146 |
| Severe thrombocytopenia, d) | 3 (2) | 2 (6) | 0.234 |
| Last Maternal CrP prior to Birth,c) | 7.21 (0 / 2.49–20.41 / 70.77) | 8.8 (0 / 2.04–29.16 / 64.93) | 0.541 |
| PROM < 24 h / > 24 h /> 1 week, d) | 36 (27) / 10 (7) / 17 (13) | 3 (10) / 0 / 12 (39) | 0.059 / 0.211 / 0.001 |
| Chorioamnionitis, d) | 8 (6) | 6 (19) | 0.026 |
| LOS d) | 27 (20) | 9 (29) | 0.211 |
| Age at BSIDII, month, e) | 24 (23–30) | 25 (24–31) | 0.323 |
| Total sepsis symptoms c) b | 3 (0 / 2–3.5 / 6) | 4 (2 / 3–5 / 7) | 0.000 |
a) n (%), χ2-test; b) mean, SD, 1-Way ANOVA; c) median, min, IQR, max; Kruskal-Wallis-Test; d) n (%), Fisher’s exact test; e) median, min – max, Mann-Whitney-U-Test
adisplayed are n of individual parental Education score categories as defined in the methods section
bdisplayed is the median total of clinical symptoms associated with EOS as defined in the methods section
Abbreviations: BPD Bronchopulmonary dysplasia, BSID Bayley Scales of Infant Development II, CBC Complete blood count, CRIB Clinical risk index for babies, EOS Early onset sepsis, LOS Late onset sepsis, PROM Premature rupture of membranes, WBC White blood cell count