Figure 9.

From tumor induction in mice to TiO₂-induced tumor regression. (A) Creation of a BALB/c Model of 4T1 Mammary Carcinoma and evaluation of the time-course effects after injection, via tail vein injection at day 5, 8, and 11 post-tumor induction, of either PBS (1X, pH 7.4; 20 mL/kg/day), free DOX (5 mg/kg/day), or TiO₂ NPs (5 mg/kg/day). At the end of the study (day 21), the mice were simultaneously sacrificed; (B) Graphical evolution of the tumor growth in treated mice (from day 5 post-tumor induction to day 21); (C) Photograph of excised breast tumors from the three mice groups (n = 5 per group), at day 21 post-tumor induction; (D) Weight of excised tumor after treatment with the indicated regimen; (E) Body weight of tumor-bearing mice during the course study. ** P < 0.01, ^# P > 0.05.