Table 2.

Known roles of NS1.

Replication	Immune Response	Pathogenesis
Formation of replication complex	Suppress IFN-β induction	Promotes vascular leakage and platelet aggregation in DENV infection
Virus assembly	Promote complement-mediated cytolysis	Contributes to hyperpermeability in umbilical vein and brain endothelial cells in ZIKV infection
Virus maturation	Promotes antibody-dependent cellular cytotoxicity (ADCC)	YFV infects liver
	Antibody-dependent cellular phagocytosis (ADCP)	JE serocomplex viruses are neuroinvasive