Table 3.

Input parameters for PBPK modeling of fexuprazan in humans.

Category	Parameter (unit)	Value	Comments
Physicochemical Properties and Blood Binding	Compound type	Base
	pKa	9.04	Determined [16]
	logP	2.38
	fup	0.0645
	B/P ratio ($R$)	0.8
Absorption	Ka (min−1)	0.0606	Predicted (See text)
	Fa	0.761	Optimized (See text)
Distribution (Kp) *	Adrenal gland	20.8	Corrected by Kp,scalar (See text)
	Adipose	4.32
	Brain	1.32
	Heart	4.60
	Kidney	16.4
	Liver	303
	Lung	87.6
	Large Intestine	40.8
	Small Intestine	124
	Spleen	17.8
	Stomach	193
Elimination	$f_{u,mic}$	0.904	Predicted (See text)
	$C{L}_{u,add}$ (L/min)	12.9	Optimized (See text)
M14 Formation by CYP3A4	$V_{max}$ (nmol/min)	248	Determined [16]
	$K_m$ (μM)	0.093
M11 Formation by CYP3A4	$V_{max}$ (nmol/min)	800	Determined [16]
	$K_m$ (μM)	15.95

* Tissue-to-plasma partition coefficients ($K_p$) were corrected from the values of rat tissues (Table 2).