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. 2021 Jun 3;9(6):1211. doi: 10.3390/microorganisms9061211

Figure 1.

Figure 1

COVID-19 mechanism of action. Phosphorylation of Akt leads to the translocation of Glut4 to the cell membrane, which facilitates glucose uptake. ACE2 induces anti-fibrotic and anti-inflammatory responses and activates Akt through the Mas receptor. COVID-19 activates AT1 and AT2 receptors, which results in the generation of pro-fibrotic and pro-inflammatory responses in the cell. Insulin R: insulin receptor, IRS1: Insulin Receptor Substrate 1, PI3K: Phosphoinositide 3-kinase, PDK1: Phosphoinositide-dependent kinase-1, GSK3: Glycogen synthase kinase, GS: Glycogen synthase, ACE2 R: ACE 2 receptor, Mas R: Mas receptor.