Table 3.
Risk of clinical events according to Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria.
| Variables | BARC > 3a No. of Events (n = 219) |
HR (95% CI) | p-Value | TIMI ≥ Minor No. of Events (n = 170) |
HR (95% CI) | p-Value | GUSTO ≥ Mod No. of Events (n = 118) |
HR (95% CI) | p-Value | Death No. of Events (n = 37) |
HR (95% CI) | p-Value | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Minor criteria |
Age ≥ 75 | 93 (26.9%) | 2.49 (1.90–3.26) | <0.001 | 67 (19.4%) | 2.13 (1.56–2.89) | <0.001 | 53 (15.3%) | 2.66 (1.85–3.83) | <0.001 | 23 (6.6%) | 5.24 (2.70–10.2) | <0.001 |
| Moderate CKD | 67 (27.2%) | 2.28 (1.71–3.05) | <0.001 | 52 (21.1%) | 2.24 (1.62–3.11) | <0.001 | 37 (15.0%) | 2.27 (1.54–3.35) | <0.001 | 17 (6.9%) | 4.18 (2.19–7.98) | <0.001 | |
| Mild Anemia | 61 (17.6%) | 1.22 (0.91–1.64) | 0.198 | 57 (16.5%) | 1.62 (1.18–2.23) | 0.003 | 21 (6.1%) | 0.66 (0.42–1.06) | 0.084 | 10 (2.9%) | 1.15 (0.56–2.37) | 0.712 | |
| Prior IS | 34 (26.0%) | 1.93 (1.34–2.79) | <0.001 | 23 (13.5%) | 1.58 (1.02–2.45) | 0.042 | 15 (11.5%) | 1.48 (0.86–2.55) | 0.156 | 5 (3.8%) | 1.55 (0.60–3.97) | 0.364 | |
| Major criteria |
Severe CKD | 39 (45.9%) | 4.06 (2.86–5.74) | <0.001 | 19 (22.4%) | 2.05 (1.27–3.31) | 0.003 | 32 (37.6%) | 7.00 (4.66–10.5) | <0.001 | 8 (9.4%) | 4.38 (2.00–9.59) | <0.001 |
| Severe Anemia | 92 (39.0%) | 4.37 (3.34–5.72) | <0.001 | 50 (21.2%) | 2.26 (1.63–3.14) | <0.001 | 72 (30.5%) | 9.17 (6.33–13.3) | <0.001 | 18 (7.6%) | 4.90 (2.57–9.34) | <0.001 | |
| Thrombocytopenia | 8 (36.4%) | 2.75 (1.36–5.57) | 0.005 | 3 (13.6%) | 1.16 (0.37–3.62) | 0.804 | 8 (36.4%) | 5.51 (2.68–11.3) | <0.001 | 3 (13.6%) | 5.89 (1.81–19.2) | 0.003 | |
| Prior ICH | 5 (29.4%) | 2.11 (0.87–5.12) | 0.099 | 2 (11.8%) | 0.92 (0.24–3.87) | 0.962 | 4 (23.5%) | 3.15 (1.16–8.53) | 0.024 | 0 (0%) | - | - | |
| Liver cirrhosis | 9 (33.3%) | 2.50 (1.28–4.88) | 0.007 | 6 (22.2%) | 2.04 (0.90–4.61) | 0.086 | 7 (25.9%) | 3.65 (1.70–7.83) | 0.001 | 2 (7.4%) | 3.08 (0.74–12.8) | 0.122 | |
| Active malignancy | 10 (52.6%) | 3.78 (2.01–7.14) | <0.001 | 6 (31.6%) | 2.72 (1.21–6.16) | 0.016 | 8 (42.1%) | 5.95 (2.90–12.2) | <0.001 | 5 (26.3%) | 13.0 (5.06–33.4) | <0.001 | |
| OAC | 1 (12.5%) | 0.83 (1.12–5.93) | 0.850 | 1 (12.5%) | 1.10 (0.15–7.83) | 0.928 | 0 (0%) | - | - | 0 (0%) | - | - | |
Values are n (%). BARC, Bleeding Academic Research Consortium; CI, confidence interval; CKD, chronic kidney disease; GUSTO, Global Use of Strategies To Open coronary arteries; HR, hazard ration; ICH, intracranial hemorrhage; IS, ischemic stroke; OAC, oral anticoagulation; TIMI, Thrombolysis in Myocardial Infarction.