Table 1.

Epidemiological Studies showing beneficial effects of polyphenols against Ischemic Stroke.

Treatment	Human	Animal	Effect	References
Mediterranean Diet and EVOO (PREDIMED study)	X		↓ Incidence of stroke ↓ Myocardial infarction ↓ AF	[73]
Mediterranean Diet (REGARDS study)	X		↓ Ischemic stroke ↓ Progression of carotid intima media thickness ↓ Diabetes	[74,76,77]
Black Tea (4 or more cups)	X		↓ Stroke risk	[78]
Resveratrol		X	↓ Infarct size ↓ Neuronal death ↑ Neurological function ↑ Shh pathway	[79,80]
Green tea extract and EGCG		X	↓ Spatial and reference memory loss ↓ Lipid peroxidation ↓ Infarct size	[79]
EGCG		X	↓ Infarct size ↑ Glutathione levels ↑ Neurological function ↓ Neuronal death ↑ Nrf2 levels	[80]
Pomegranate		X	↑ Memories deficits due to MCAO	[81]
Salvianolic acid B		X	↓ Infarct size ↑ Neurological function ↓ Inflammation ↑ SIRT1 expression	[82]

↑ = increase and improve; ↓ = reduce.