Table 3.
Overview of animal studies investigating the safety and efficacy of bacteriophages or phage-derived enzymes in the treatment of chronic rhinosinusitis.
| Authors (Year) | Pathogen | Animal Model + Application Method | Included Subjects | Phage | Safety | Efficacy |
|---|---|---|---|---|---|---|
| Fenton M. et al. (2010) [20] | S. aureus | Mice, intranasal instillation | 14 | Phage lysin CHAPk from bacteriophage K |
NS | Two-log reduction in S. aureus cells 1 h after single application |
| Drilling A. et al. (2014) [9] | S. aureus | Sheep, frontal rinsing via mini-trephinations | 27 | CT-SA cocktail |
No histological changes to frontal sinus mucosa | Significant reduction of biofilm mass |
| Drilling A. et al. (2017) [8] | S. aureus | Sheep, frontal rinsing via mini-trephinations | 21 | NOV012 cocktail |
No histological changes to frontal sinus mucosa | NS |
| Fong S. et al. (2019) [19] | P. aeruginosa | Sheep, frontal rinsing via mini-trephinations | 32 | CT-PA cocktail |
No histological changes to frontal sinus mucosa | Significant reduction of biofilm mass |
Abbreviations: NS = not specified.