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. 2021 Jun 1;10(6):892. doi: 10.3390/antiox10060892

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The graphical representation of the neuroprotective mechanism of estradiol against glutamate-induced neurodegeneration in developing rat brain. Exogenous glutamate (single subcutaneous injection of 10 mg/kg) treatment increased brain oxidative stress associated with the dysregulated MAP kinase pathway mediated neuroinflammation, synapse loss and neurodegeneration in postnatal 7-day rat brain. Co-administration of 17β-estradiol with glutamate alleviated glutamate-induced neurodegeneration in the developing rats.