Table 1.
Nanoparticle size analysis and lattice parameters of identified biphasic features of lamellar (Lα) phase in coexistence with an inverse bicontinuous cubic Pn3m phase. For determination of the structural features of the produced nano-self-assemblies, SAXS experiments were conducted at two different temperatures: 25 and 37 °C; whereas NTA measurements were performed for investigating their size characteristics.
| Sample Name a | TQ (mg/mL) | TFR (µL/min) |
Space Group | Lattice Parameter (nm ± Error%) 25 °C 37 °C |
Size (nm) c Mean ± SD Mode ± SE |
||
|---|---|---|---|---|---|---|---|
| A1 | 0 | 100 | Lα Pn3m |
9.63 20.18 ± 0.03 |
9.48 19.70 ± 0.05 |
115.5 ± 42 | 134.8 ± 3.6 |
| A2 | 0 | 50 | Lα Pn3m |
9.51 20.18 ± 0.03 |
9.39 19.70 ± 0.05 |
119.7 ± 42 | 114.4 ± 3.8 |
| A3 | 1 | 100 | Lα Pn3m |
9.42 19.62 ± 0.02 |
9.43 19.36 ± 0.02 |
124.3 ± 38 | 126 ± 5.5 |
| A4 | 1 | 50 | Lα Pn3m |
9.56 20.18 ± 0.03 |
9.43 19.70 ± 0.05 |
139.8 ± 48 | 136.7 ± 3.2 |
| A5 | 2.5 | 100 | Lα Pn3m |
9.52 19.26 ± 0.04 |
9.36 19.27 ± 0.03 |
141.2 ± 49 | 145.5 ± 6.0 |
| A6 | 2.5 | 50 | Lα Pn3m |
9.46 19.87 ± 0.02 |
9.33 19.74 ± 0.02 |
150.1 ± 61 | 140.3 ± 2.7 |
| A7 | 5 | 100 | Lα Pn3m |
9.46 19.6 ± 0.02 |
9.44 19.18 ± 0.01 |
147.7 ± 45 | 150.5 ± 7. |
| A8 | 5 | 50 | Lα Pn3m |
9.48 19.71 ± 0.04 |
9.41 19.62 ± 0.06 |
164 ± 54 | 144.6 ± 8.1 |
| A9 | 0 | Batch | N.I. | N.I. b | 116.8 ± 45 | 102.3 ± 14.1 | |
| A10 | 2.5 | Batch | N.I. | N.I. b | 141.2 ± 44 | 135.1 ± 3.7 | |
a All nanodispersions were produced at a constant FRR of 20, and constant ethanol and lipid (citrem plus SPC) concentrations of 2.86 and 1.9 wt%, respectively. b Samples A9 and A10 were not investigated (N.I.). c Mean and mode nanoparticle sizes are presented with standard deviations and standard errors, respectively.