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Percentage changes in BMD before and during the zinc treatment. Dashed and solid lines indicate the data of male and female patients, respectively. The significance of differences in −6, 6, and 12 months vs. baseline was evaluated by the Wilcoxon signed-rank test (* P < 0.05, ** P < 0.01, and *** P < 0.001), while that between genders at each time point was assessed by the Wilcoxon rank-sum testing († P < 0.05). BMD, bone mineral density.
