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. 2021 May 28;10(6):867. doi: 10.3390/antiox10060867

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The Nrf2-mediated expression of antioxidant enzymes was elevated in TauCl-treated mice. (A,B) Nuclear localization of Nrf2 was assessed by immunofluorescence staining (A) and Western blot analysis (B). (C) The expression of HO-1 was determined by Western blot analysis. (D) Nrf2-mediated antioxidant gene expression was measured by qPCR. Results are expressed as means ± SD (n = 3 for each group), analyzed by Student’s t-test. **^, *** Significantly different between groups compared (** p < 0.01; *** p < 0.001). Scale bar, 200 µm.