Table 1.
Selected applications of liposomes with metallic nanoparticles in cancer therapy.
| Author | Year | Nanostructures | Synthesis Method | Nanostructures’ Size | Cell/Tissue | Kind of Therapy | Results |
|---|---|---|---|---|---|---|---|
| Bromma [56] |
2019 | AuNPs entrapped in lipid nanoparticles | rapid-mixing method | 53 nm | Breast cancer cells, MDA-MB-231 | Radiotherapy | The addition of LNPs into tumor cells produced a 27% enhancement in tumor cell death |
| Bao [53] |
2014 | PTX-conjugated GNPs (PTX–PEG400@GNPs) in liposomes | thin film hydration | 3.41 nm gold core | A murine liver cancer model | The drug delivery system | Maintains the superiority of both vehicles and improves the performance of hybrid systems |
| Chitchrani [49] |
2010 | AuNPs in liposome-based system | thin film hydration | 105 nm | Cervical cancer cells, HeLa | The assessment of cellular uptake and transport | Au NP–liposomes demonstrated that they reside in lysosomes |
| Liu [45] |
2020 | Au nanoparticles and perfluorohexane nanoparticles encapsulated in lipid shell | film hydration method coupled with a double emulsion method | 108 nm | Human anaplastic thyroid cancer cells, C643 | Low-intensity focused ultrasound diagnosis ablation | An optional therapeutic platform for treating patients with drug-resistant cancer |
| Wang [57] |
2017 | Loading resveratrol (Res) in chitosan (CTS) modified liposome and coated by gold nanoshells (GNS@CTS@Res-lips). | mediation of CTS | 115 nm | Cervical cancer cells, HeLa | Photothermal therapy | The nanocarriers displayed a synergistic antitumor effect of chemo photothermal therapy compared with PTT or chemotherapy alone |
| Zhu [16] |
2018 | Carboxyl-modified Au@Ag core-shell nanoparticles (Au@Ag@MMTAA) contained in the liposomes (DSPE-PEG2000-NH2) | thin film hydration | 215 nm | Breast cancer cells, SKBR3 | The assessment of cellular uptake and transport | The nanohybrids entered cells mainly through clathrin-mediated endocytosis and tended to attach on the cell, the highest mortality in vitro after laser treatment, surface before arriving in acidic lysosomes |
| Rengan [36] |
2014 | The Lipos Au particles | thin film hydration | 100–150 nm | Breast cancer cells, MDA-MB-231 | The drug delivery system and photothermal therapy | The efficient deployment for drug delivery application using NIR laser irradiation, enhanced parameters of drug delivery, and optical imaging, the Lipos Au NPs exhibited their true multifunctional ability by emitting good signals in CT X-ray analysis |
| Zhang [51] |
2016 | Gold conjugate-based liposomes with hybrid cluster bomb structure | thin film dispersion method, | 115–150 nm | Xenograft Heps tumor-bearing mice | The multi-order drug delivery system | The time-release mode for tumor treatment using antitumor drugs |
| Sharifabad [52] |
2016 | Liposome-capped core-shell mesoporous silica-coated superparamagnetic iron oxide nanoparticles called ‘magnetic protocells’ | lipid hydration | 53 nm | Breast cancer cells, MCF7 and likely glioblastoma cells, U87 | The drug delivery system | Loaded nanoparticles under alternating magnetic field exhibited nearly 20% lower survival rate of cancer cells |
| Zheng [55] |
2018 | liposome-containing paclitaxel (PTX) and superparamagnetic iron oxide nanoparticles (SPIO NPs), PTX/SPIO-SSL-H7K(R2)2, | thin film hydration | 3.41 nm gold core | human breast cancer cell line, MDA-MB-231 | The drug delivery system | Antitumor effect and enhancement of MRI parameters |
AuNPs—Au Nanoparticles; LNPs—Lipos nanoparticles; PTX—paclitaxel; GNPs—Gold Nanoparticles; PEG—Polyethylene Glycol; GNS—gold nanoshells; PTT—Photothermal therapy; DSPE—1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine; MMTAA—2-mercapto-4-methyl-5- thiazoleacetic acid; CT—computed tomography; SPIONPs—superparamagnetic iron oxide nanoparticles.