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. 2021 May 26;10(6):1322. doi: 10.3390/cells10061322

Figure 2.

Figure 2

Genetic deletion of Myo1c in mice results in a decreased visual function. Dark-adapted scotopic ERGs were recorded in response to increasing light intensities in cohorts of control wild-type (WT) (blue bars, blue-traces) and Myo1c-KO (red bars, red-traces) mice, aged two months old (A,C), and six months old (B,D). Two-month-old Myo1c-KO mice had lower dark-adapted a- and b-wave amplitudes compared with those of controls (post-hoc ANOVA: a-waves, p < 0.0068; b-waves, p < 0.0098, n.s. not significant.), in particular at higher light intensities (−40, −30, −20, −10, 0 dB). Six-month-old Myo1c-knockout mice had lower dark-adapted a- and b-wave amplitudes compared with those of controls (post-hoc ANOVA: a-waves, ** p < 0.005; b-waves, ** p < 0.005), in particular at higher light intensities (−40, −30, −20, −10, 0 dB). Photoreceptor cell responses (a-waves), which drive the b-waves, were equally affected in 6-month-old Myo1c-KO animals (both reduced on average between 38 and 45% of WT animals). Data are expressed as mean ± S.E. (Myo1c-KO mice and WT mice, n = 8 per genotype and age-group; 50:50 male-female ratio).