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Spectrum of toxicity observed in clinical trials investigating novel ADCs. Abbreviations: ILD, interstitial lung disease; FcγR, Fragment crystallizable-gamma receptor; T-DXd, trastuzumab deruxtecan; MMAE, Monomethyl auristatin E; MMAF, Monomethyl auristatin F; DM1, mertansine/emtansine; DM4, ravtansine/soravtansine; seco-DUBA, seco-duocarmycin-hydroxybenzamide-azaindole; LVEF, Left Ventricular Ejection Fraction; Abs, antibodies. Created with Biorender.com (accessed on 15 March 2021).
