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. 2021 Jun 6;10(6):1405. doi: 10.3390/cells10061405

Figure 7.

Figure 7

The effect of antioxidants (2 μM APDC, 5 mM NAC) in conjunction with 200 μM hydroquinone (HQ; 18 h) on the release of LDH (A) and IL-18 (B), and on the intracellular NLRP3 (C) levels in IL-1α-primed ARPE-19 cells. Data were combined from four (A,B) or 2 (C) independent experiments containing four (A, B) or two (C) parallel samples per group. IL-18 concentrations in (B) were 0.745–10.597 pg/mL in the IL-1α, 6.515–83.423 pg/mL in the IL-1α + HQ 200 μM, 2.58–26.253 pg/mL in the IL-1α + APDC + HQ 200 μM, and 7.721–26.506 pg/mL in the IL-1α + NAC + HQ 200 μM group. Absorbance values in (C) were 0.62–0.72 in the control, 2.171–2.824 in the IL-1α + HQ 200 μM, 1.816–2.564 in the IL-1α + APDC + HQ 200 μM, and 1.266–2.25 in the IL-1α + NAC + HQ 200 μM group. Results are presented as mean ± SEM. * p < 0.05, *** p < 0.001, **** p < 0.0001, ns = not significant, Mann-Whitney U-test.