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The role of angiopoietins in pre- and post-ovulatory follicles. Before ovulation, the ANGPT1/ANGPT2 ratio increases, leading to vascular maturation, whereas after the LH surge, the level of ANGPT2 increases compared to ANGPT1, leading to the destabilisation of vessels and pericyte detachment. Abbreviations—ANGPT1: angiopoietin 1; ANGPT2: angiopoietin 2. (Created with BioRender.com, accession date: 29 May 2021).
