Figure 6.

Protein carbonylation cardiac content evaluated by slot blot in (A) infant mice and (B) adult mice exposed to a cumulative dose of 6.0 mg/kg MTX (experiment 2, infant and adult mice were euthanized 17 or 7 days after the last administration, respectively). Values are expressed as mean ± SD and were obtained from six animals from each treatment group. Statistical comparisons were made using the t-test: * p < 0.05, MTX 6.0 mg/kg vs. control. OD: optic density, M: mitoxantrone, C: control.