Figure 3.

Pedigree, sequencing chromatogram, clinical photos, and panoramic radiograph of Family 3. (A) Pedigree of Family 3. The black filled symbol indicates the affected individual, and the proband is indicated by a black arrow. Plus signs above the symbols indicate participating individuals. (B) Sequencing chromatogram of the proband. Nucleotide sequences are shown above the chromatogram. The red arrow indicates the location of the mutation (NM_000089.4:c.1171G>A) (R: A or G). (C–E) Clinical photos of the proband’s mother at age 37 years. There are some attritions in the mandibular anterior teeth and premolars (white arrow); however, the maxillary anterior teeth look normal. (F) Panoramic radiograph of the proband’s mother at age 37 years. (G) Panoramic radiograph of the proband at age 4 years and 8 months.