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Changes in plasma exosomes (shown as total sEV protein level) of HNSCC patients treated with cetuximab/IMRT/ipilimumab. Five patients had recurrence and 13 were NED at 2 yrs. after therapy. Note decreased exosome protein in patients who remained NED for >2 yrs. * p = 0.05; ** p = 0.005. ND= normal donors. Reproduced from ref [80].
