Figure 3.

Suboptimal lysosome fusion permits A. fumigatus germination within the airway epithelium. (A) Proportion of A. fumigatus spores and germlings within A549 alveolar epithelial cells. (B) Proportion of internalized spores and germlings within phagolysosomes of A549 cells. (C) Proportion of internalized spores and germlings within unfused phagosomes of A549 cells. Data represents mean and standard deviation of five biological replicates. Differences in proportions between time points for spores and germlings were independently tested using the Fischer Exact Test. **** p < 0.0001.