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. 2021 Jun 7;11(6):1048. doi: 10.3390/diagnostics11061048

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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ART successfully discriminated citrullinated from non-citrullinated CXCL10. (A) In vitro citrullination of recombinant, full length CXCL10 by PAD2 resulted in loss of detection by commercial anti-CXCL10 antibody ab9807 (upper left), and a substantial reduction in detection by mAb-A2 (lower left). Citrullination was confirmed using an anti-citrulline antibody (upper right). Detection of citrullinated CXCL10 by mAb-RG2 was unaffected. (B) ELISA using mAb-RA2 (left) or mAb-RG2 (right) confirmed that detection of citrullinated CXCL10 by mAb-RA2 was abrogated, whilst detection by mAb-RG2 was unaffected. n = 3 replicates per data point.