Table 1.
Size distribution with relative populations weight by intensity of blank and SVT loaded micelles measured at time zero and after 48 h and 1-month storage at room temperature (SVT concentration 1 mg/mL).
| Time Zero | 48 h | 1 Month | ||||
|---|---|---|---|---|---|---|
| Code a | PdI | Size (nm and % Intensity) | PdI | Size (nm and % Intensity) | PdI | Size (nm and % Intensity) |
| TN | 0.081 | 12.4 ± 3.6 (100) | 0.024 | 11.7 ± 2.8 (100) | 0.046 | 11.6 ± 3.0 (100) |
| TNSVT | 0.142 | 13.2 ± 3.8 (100) | 0.087 | 12.3 ± 3.8 (100) | 0.032 | 11.7 ± 3.0 (100) |
| MN | 0.26 | 5.0 ± 1.5 (49) | 0.436 | 6.2 ± 2.5 (49.7) | 0.201 | 4.9 ± 1.5 (41.6) |
| 27.8 ± 8.8 (42.7) | 34.0 ± 15.1 (40.6) | 31.0 ± 10.8 (51.6) | ||||
| 165.1 ± 52.3 (8.3) | 873.1 ± 480.8 (5.2) | 158.8 ± 41.4 (6.9) | ||||
| MNSVT | 0.348 | 5.0 ± 1.2 (48.9) | 0.367 | 5.3 ± 1.5 (42.1) | 0.509 | 5.7 ± 1.6 (42.3) |
| 25.5 ± 6.7 (40.2) | 25.0 ± 6.5 (40.7) | 32.7 ± 10.8 (39.5) | ||||
| 98.6 ± 17.8 (10.9) | 636.6 ± 124.6 (16.7) | 1443 ± 794.2 (18.2) | ||||
a M= 10 mM TPGS:10 mM P407 micelles; N = saline solution as vehicle; SVT = simvastatin; T = 20 mM TPGS micelles.