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Amount of encapsulated SVT (as % of initial SVT, concentration 1 mg/mL) in micelles after 24 h, 48 h and 1 month at 4 and 25 °C.
| 4 °C | 25 °C | |||
|---|---|---|---|---|
| Storage Time | TNSVT (SVT%) |
MNSVT (SVT%) |
TNSVT (SVT%) |
MNSVT (SVT%) |
| 24 h | 96.9 ± 1.1 | 94.6 ± 6.8 | 92.7 ± 3.9 | 87.0 ± 13.9 |
| 48 h | 91.8 ± 6.1 | 90.3 ± 12.1 | 86.7 ± 4.2 | 80.3 ± 8.8 |
| 1 month | 79.5 ± 3.1 | 100.7 ± 0.3 | 32.4 ± 1.7 | 80.6 ± 4.1 |
M = 10mM TPGS:10 mM P407 micelles; N = saline solution as vehicle; SVT = simvastatin; T = 20 mM TPGS micelles.
