Table 5.

The top 5 nodes with each link prediction validation label, ranked by lowest HeteSim scores. Lower standardized HeteSim scores corresponds to a stronger relationship. The complete list of top ranked nodes (n = 180, equivalent to the top 20 ranked nodes for each node type) can be found in Supplementary Table S1.

Node	Drug Class	Node Type	Standardized HeteSim Score	Predicted Link	Pharmacokinetics
Top 5 PROVEN Nodes
Chloroquine	glycoproteins big	OrganicChemical	0.073	treats	Primary
Glycyrrhizic Acid	anti-inflammatory	OrganicChemical	0.074	treats	Primary
Quinine	anti-inflammatory	OrganicChemical	0.077	treats	Primary
Chloroquine	antimalarial	OrganicChemical	0.077	treats	Primary
Fluoroquinolones	antimalarial	OrganicChemical	0.077	treats	Adjunctive
Top 5 DISPROVEN Nodes
Polyamines	antimalarial	OrganicChemical	0.080	treats	Other
Complement System Proteins	neuraminidase inhibitors	ImmunologicFactor	0.101	prevents	Other
Dopamine Receptor	neuraminidase inhibitors	Receptor	0.103	treats	Other
Chemokine (C-C Motif) Receptor 5|CCR5	envelope protein	Receptor	0.104	treats	Other
Antiviral prophylaxis	nucleoside analogs	TherapeuticOr PreventiveProcedure	0.107	neg treats	Primary
Top 5 UNCLEAR Nodes
small molecule	immunomodulators	OrganicChemical	0.069	prevents	N/A
ebselen	anti-inflammatory	OrganicChemical	0.077	treats	N/A
Fluticasone propionate	anti-inflammatory	OrganicChemical	0.079	treats	N/A
Quinolone Antibacterial Agents	anti-inflammatory	OrganicChemical	0.082	prevents	N/A
Morphine	anti-inflammatory	OrganicChemical	0.084	treats	N/A
Top 5 MISSING Nodes
small molecule	glycoproteins big	OrganicChemical	0.056	prevents	N/A
RABBIT SERUM	glycoproteins big	OrganicChemical	0.061	N/A	N/A
Esters	anti-inflammatory	OrganicChemical	0.070	N/A	N/A
Edetic Acid	glycoproteins big	OrganicChemical	0.074	treats	N/A
small molecule	protease inhibitors	OrganicChemical	0.075	N/A	N/A