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. 2021 Jun 9;10(6):1448. doi: 10.3390/cells10061448

Figure 1.

Figure 1

Effects of S961 treatment on vascular function of the thoracic and abdominal aorta. (A): Assessment of endothelium-dependent vascular response to acetylcholine (Ach) 30 min after administration in the thoracic aorta (TA, VEH n = 8, S961 n = 7) and abdominal aorta (AA, VEH n = 8, S961 n = 7) (B): Assessment of endothelium-independent vasodilation induced by sodium nitroprusside (SNP) 30 min after iv administration in thoracic aorta (TA, VEH n = 8, S961 n = 8) and abdominal aorta (AA, VEH n = 8, S961 n = 7). (C): Nitric oxide (NO) production in isolated TA (VEH n = 5, S961 n = 7) and AA (VEH n = 8, S961 n = 11), without PVAT. (A,B): significance assessed by Two-way ANOVA (aorta part and treatment being the two factors), normality confirmed by Shapiro-Wilk test, variance by F-test, with post hoc Sidak test. (C): significance assessed by two-sided t-test with Welch’s correction (normality was assessed using the Shapiro–Wilk test). * p < 0.05, *** p < 0.001, **** p < 0.0001.