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. 2021 Jun 9;10(6):1331. doi: 10.3390/foods10061331

Figure 6.

Figure 6

Protective effects of XN against AFB1-induced DNA strand breaks. The effects of XN (0.01, 0.1, 1, and 10 µM), AFB1 (10, 20, and 30 µM) and the AFB1 (30 µM)—XN (0.01, 0.1, 1, and 10 µM) combinations on DNA damage induction after 24 h of exposure. Data are expressed as % of “comet tail” DNA. 0 is the solvent control (1% DMSO).NC is the negative control (growth medium). PC is the positive control—BaP (30 μg/mL). The lower dashed line represents the median value of the % tail DNA in the solvent control. The upper red dashed line represents the median % of tail DNA in the cell population exposed to AFB1 (30 µM). The asterisks (*) denote a statistically significant difference (Kruskal–Wallis nonparametric test and Dunn’s multiple comparison test) between the solvent control and the AFB1, XN, and their combinations exposed cells (*** p ≤ 0.001). The red dots (•) denote a statistically significant difference (Kruskal–Wallis nonparametric test and Dunn’s multiple comparison test) between the cells exposed to AFB1 (30 µM) and to the AFB1-XN combinations (•• p ≤ 0.01; ••• p ≤ 0.001).