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. 2021 Jun 9;10(6):1331. doi: 10.3390/foods10061331

Figure 7.

Figure 7

Protective effects of XN against AFB1-induced DNA double-strand breaks (DSBs). The effects of XN (0.01, 0.1, 1, and 10 µM), AFB1 (10, 20, and 30 µM) and the AFB1 (30 µM)—XN (0.01, 0.1, 1, and 10 µM) combinations on DNA DSB induction were assessed after 24 h of exposure. The data (fluorescence FL1-H) are normalized to the average fluorescent signal of the solvent control (0; 1% DMSO), and the lower dashed line denotes the median value of the relative fluorescence of 0. NC is the negative control (growth medium). PC is the positive control—ET (1 μg/mL). The upper red dashed line represents the median relative fluorescence in the cell population exposed to AFB1 (30 µM). The asterisks (*) denote statistically significant difference (linear mixed-effects model (lme), the R program) between the solvent control and the AFB1, XN, and their combinations exposed cells (* p ≤ 0.05, ** ≤ p 0.01). The red dots (•) denote a statistically significant difference (linear mixed-effects model (lme), the R program) between the cells exposed to AFB1 (30 µM) and to the AFB1-XN combinations (• p ≤ 0.05).