Table 1.
Characteristics of participants stratified by rs7901695 genotype.
| rs7901695 | T/T | C/T | C/C | p-Value |
|---|---|---|---|---|
| N | 442 | 317 | 51 | |
| Men/women (%) | 48/52 | 49/51 | 43/57 | |
| Genotype frequency | 54.57% | 39.14% | 6.30% | >0.05 |
| Age (years) | 40.94 | 40.93 | 40.85 | 0.942 |
| BMI (kg/m2) | 28.7 (6.6) | 28.2 (6.8) | 28.3 (6.4) | 0.574 |
| BMI < 25.0 (kg/m2) | 143 (32.6%) | 111 (35.9%) | 16 (32.0%) | 0.856 |
| BMI 25.0–29.9 (kg/m2) | 153 (34.9%) | 105 (34.0%) | 16 (32.0%) | |
| BMI ≥ 30.0 (kg/m2) | 142 (32.4%) | 93 (30.1%) | 18 (36.0%) | |
| Total body fat content (%) | 31.7 (9.8) | 30.8 (9.3) | 32.7 (9.9) | 0.272 |
| WHR | 0.932 (0.086) | 0.925 (0.091) | 0.915 (0.087) | 0.325 |
| Visceral fat content (%) | 37.8 (12.8) | 36.3 (10.8) | 36.7 (13.1) | 0.732 |
| Subcutaneous fat content (%) | 62.1 (13.2) | 63.7 (10.8) | 63.3 (13.1) | 0.738 |
| Visceral/subcutaneous fat ratio | 0.698 (0.465) | 0.633 (0.419 | 0.661 (0.419) | 0.732 |
| Frequency of prediabetes or diabetes | ||||
| Yes | 223 (50.5%) | 159 (50.2%) | 26 (51.0%) | 0.992 |
| No | 219 (49.5%) | 158 (49.8%) | 25 (49.0%) | |
| Fasting blood glucose (mg/dl) | 96.4 (26.4) | 96.1 (19.9) | 104.5 (31.8) | 0.613 |
| Blood glucose at 30′ of OGTT (mg/dl) | 146.9 (34.5) | 145.4 (36.2) | 154.3 (51.7) | 0.811 |
| Blood glucose at 60′ of OGTT (mg/dl) | 131.5 (47.7) | 130.6 (48.8) | 137.1 (63.4) | 0.913 |
| Blood glucose at 120′ of OGTT (mg/dl) | 99.3 (33.0) | 99.5 (36.0) | 101.0 (58.3) | 0.660 |
| Glucose AUC during OGTT | 0.22 (95% CI: 0.21–0.23) | 0.22 (95% CI: 0.21–0.23) | 0.23 (95% CI: 0.19–0.28) | 0.349 |
| HbA1c | 5.6 (1.1) | 5.5 (1.1) | 5.6 (1.1) | 0.427 |
| Fasting insulin (IU/mL) | 12.8 (9.3) | 12.1 (10.4) | 11.1 (7.0) | 0.072 |
| Insulin AUC during OGTT | 0.14 (95% CI: 0.13–0.15) | 0.13 (95% CI: 0.12–0.14) | 0.4 (95% CI: 0.10–0.17) | 0.118 |
| HOMA-IR | 3.1 (2.6) | 2.9 (2.7) | 2.8 (2.2) | 0.084 |
| HOMA-B | 162.5 (218.9) | 157.6 (152.8) | 142.7 (106.4) | 0.287 |
| CIR30 | 0.9 (0.9) | 0.8 (0.7) | 0.8 (0.8) | 0.495 |
| Daily energy intake (kcal) | 1814.7 (702.7) | 1779.3 (708.6) | 1610.1 (538.1) | 0.216 |
| % of daily energy from carbohydrates | 48.0 (8.7) | 47.0 (9.0) | 47.2 (5.4) | 0.329 |
| % of daily energy from protein | 18.8 (4.6) | 19.1 (5.2) | 19.9 (3.6) | 0.334 |
| % of daily energy from fat | 31.1 (7.5) | 31.4 (7.7) | 31.2 (5.2) | 0.154 |
| Protein intake (n in the low/high quantiles) | 140/128 | 92/94 | 10/20 | |
| Carbohydrate intake (n in the low/high quantiles) | 123/145 | 100/86 | 19/11 | |
| Fat intake (n in the low/high quantiles) | 133/135 | 95/91 | 14/16 | |
| Daily physical activity level, n (%) | ||||
| Low | 28 (6.3%) | 28 (8.8%) | 3 (5.9%) | 0.246 |
| Moderate | 89 (20.1%) | 65 (20.5%) | 16 (31.4%) | |
| High | 325 (73.5%) | 224 (70.7%) | 32 (62.7%) |
Data represent arithmetic mean values and standard deviations (SDs).