Table 1.
PD indices related to the efficacy of different antimicrobials.
| Antimicrobial Activity | PK/PD Index | ||
|---|---|---|---|
| Concentration-dependent activity | |||
| Aminoglycosides | fCmax/MIC | ||
| Quinolones | fAUC24/MIC | ||
| Time-dependent activity | |||
| β-lactams | fT>MIC | ||
| Penicillins | |||
| Cephalosporins | |||
| Carbapenems | |||
| Concentration-dependent activity with time-dependence | |||
| Vancomycin | Fosfomycin | fAUC24/MIC | |
| Linezolid | Fluoroquinolones | ||
| Daptomycin | Colistin | ||
fCmax/MIC: Free-drug maximum concentration to the MIC; fT>MIC: The percentage of time that the antimicrobial free serum concentration remained above the MIC; fAUC24/MIC: The area under the free concentration-time curve over 24 h divided by the MIC.