Table 2.

Published studies that review breakpoints by applying the PK/PD criteria.

Reference	Bacteria	Antimicrobials
		Betalactams	Others
DeRyke et al. [64]	P. aeruginosa A. baumanii E. coli Klebsiella spp.	Cefepime Ceftazidime Ceftriaxona Imipenem Meropenem Piperacillin/tazabactam	Ciprofloxacin Levofloxacin
Frei et al. [65]	Enterobateriaceae P. aeruginosa A. baumannii	Aztreonam Cefepime Ceftizoxime Cetazidime Ertapenem Imipenem Meropenem Piperacillin/tazobactam	Ciprofloxacin Gentamicin Levofloxacin Tobramycin
Asín et al. [61]	Enterococcus Staphylococcus β-Haemolytic streptococci Other streptococci S. pneumoniae	Amoxicillin Cefepime Cefotaxime Cloxacillin Ertapenem Imipenem Meropenem Piperacillin/tazobactam	Levofloxacin Vancomycin Daptomycin Tigecycline Linezolid
Burgess et al. [66]	Neisseria meningitidis	Ampicillin Cefotaxime Ceftriaxone Ciprofloxacin Meropenem Penicillin G	Azithromycin Chloramphenicol Doxycycline Levofloxacin Minocycline Rifampicin Sulphafurazole Tetracycline Co-Trimoxazole
Zuur et al. [68]	Mycobacterium tuberculosis		Isoniazid Pyrazinamide Rifampin
Deshpande et al. [67]	Mycobacterium tuberculosis		Levofloxacin