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. 2021 Jun 9;11(6):862. doi: 10.3390/biom11060862

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scheme 1 — Synthesis of TSCs HL¹-HL³ and H₂L⁴. Reagents and conditions: (x) E, H·TFA (or H), 1,1,3,3-tetramethylguanidine (TMG), dry CH₂Cl₂/THF 1:1, 50 °C, 24 h, purification by column chromatography; (xi₁) I₁, water, 12 M HCl, 60 °C, 3 h, Et₃N, purification by column chromatography; (xi₂) I₂, water, 12 M HCl, 60 °C, 4 h, Et₃N, purification by column chromatography; (xii) thiosemicarbazide, C₂H₅OH, 80 °C, 2–3 h.