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. 2021 Jun 10;22(12):6245. doi: 10.3390/ijms22126245

Figure 4.

Figure 4

Quantification of the different retinal ganglion cells (RGC) types responses. (A). Percentages of the different functional types of RGC (ON, OFF, and ON/OFF) recorded in the control/wild type (WT retinas (n = 4) and those injected with 10:3 mM NMDA/KA (n = 4; t-test; p ≤ 0.001 for ON and ON/OFF cells). A significant decrease in the number recorded cells was observed for the NMDN/KA injected retinas (t-test; p = 0.018). The total number of ON, OFF, and ON/OFF cells were 89, 35, and 113 for the WT retinas and 48, 2, and 0 for NMDA/KA injected eyes, respectively. Data are presented as mean ± SEM. (B). Examples of sustained (left) and transient (right) post stimulus raster plot of light responses are represented for each RGC type (ON, OFF, and ON/OFF) for both retinas from the WT/control animals and those injected with NMDA/KA. The light stimulus is represented above the plots. A corresponding cumulated post stimulus time histogram (PSTH) for all recording examples is also shown for all RGC types. The firing frequency evoked by the light stimulus is greatly reduced in the NMDA/KA group. (***, p ≤ 0.001).