Table 3.
HOTAIR–miRNA–mRNA axes in breast cancer progression.
| LncRNA | MiRNA | mRNA | Cell Lines | Roles | Reference |
|---|---|---|---|---|---|
| HOTAIR ↑ | miR-34a ↓ | SOX2 ↑ | MCF7-derived BCSC | cancer stemness ↑ | [62] |
| HOTAIR ↓ | miR-7 ↑ | SETDB1 ↓ | MDA-MB-231, MCF7 and their BCSC | invasion, migration, metastasis ↓ | [64] |
| HOTAIR ↑ | miR-20a-5p ↓ | HMGA2 ↑ | MDA-MB-231 | proliferation, migration ↑; apoptosis ↓ | [67] |
| HOTAIR ↑ | miR-206 ↓ | Bcl-w ↑ | MCF7, T47D | proliferation ↑ | [68] |
| HOTAIR ↑ | miR-601 ↓ | ZEB1 ↑ | MCF7, MDA-MB-231 | invasion, migration ↑ | [69] |
| HOTAIR ↑ | miR-129-5p ↓ | FZD7 ↑ | SKBR3, MCF7 | invasion, migration ↑ | [41] |
| HOTAIR ↓ | miR-204 ↑ | FAK ↓ | MDA-MB-231, Hs-578T | migration, vasculogenic mimicry ↓ | [78] |
| HOTAIR ↓ | miR-34a ↑ | β-catenin ↓ | MDA-MB-231/453, MCF7 | proliferation and mobility ↓ | [97] |
| HOTAIR ↑ | miR-449b-5p ↓ | HSPA1A ↑ | MDA-MB-231, MCF7 | radioresistance ↑ | [108] |
| HOTAIR ↓ | miR-218 ↑ | / | MCF7, SKBR3, MDA-MB-231 | radiosensitivity ↑ | [40] |