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. 2021 Jun 10;22(12):6249. doi: 10.3390/ijms22126249

Figure 2.

Figure 2

Wnt-C59 suppressed the cytokine upregulation and NF-κB activity in multiple organs of endotoxemic mice. C57BL/6 mice were i. p. injected with 0 or 60 mg/kg of Wnt-C59 and then with 0 or 25 mg/kg of lipopolysaccharide (LPS) after 2 h. (A–I) The cytokine mRNA levels in the kidney, lung, and liver were quantified via reverse transcription–quantitative polymerase chain reaction (n = 4). (J–L) The target-DNA binding activity of NF-κB in the kidney, lung, and liver was measured using ELISA (n = 4). * p < 0.05, ** p < 0.01, and *** p < 0.001 compared with the group injected with 25 mg/kg of LPS. ### p < 0.001 compared with the control group (unpaired t-test).