Table 4.
Studies in peripheral blood mononuclear cells.
| Study ID | Study Outcome |
Study Design |
Subjects | Sample Preparation Method |
Analytical Techniques |
Data Processing Software |
Statistical Analysis Software |
Results |
|---|---|---|---|---|---|---|---|---|
| Wójcik 2019 [31] |
Ps diagnosis PsA diagnosis |
Untargeted | 32 Ps 16 PsA 16 HC |
LLE SPE |
GC-MS LC-MS/MS |
N/A | Statistica | Higher 8-isoPGF2a and 4-HNE in PsA, whereas 4-HNE-His adducts were higher in Ps. Increased eicosanoids in Ps and PsA: PGE1, LTB4, 13HODE, TXB2. Eicosanoids 15-d-PGJ2 and 15-HETE were elevated in Ps and reduced in PsA. |
Abbreviations: Ps, psoriasis; PsA, psoriatic arthritis; HC, healthy controls; SPE, solid-phase extraction; LLE, liquid-liquid extraction; LC-MS, liquid chromatography-mass spectrometry; LC-MS/MS, liquid chromatography-tandem mass spectrometry; GC-MS, gas chromatography-mass spectrometry.