Figure 1.

(A) CT/PET scan performed prior to and after three treatment cycles of pembrolizumab showed a good disease control with volume reduction in all the involved sites. (B) CT/PET scan performed during the follow-up (after 8 months from the last pembrolizumab administration) demonstrated a further reduction in cancer metabolism coupled with a sclerotic reaction. Arrows indicate the point where SUV reduction is more evident. (C) Cartoon representing the possible mechanism responsible for (muscle) immune-related adverse events (irAEs). Pembro: pembrolizumab; AA: auto-antigens; TAA: tumor-associated antigens.