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. 2021 Jun 10;22(12):6256. doi: 10.3390/ijms22126256

Figure 4.

Figure 4

Cytotoxicity of different BacSp222 forms against murine monocyte-macrophage cells RAW 264.7 and murine primary dermal fibroblasts MDF. The cells were incubated for 4 h in a medium containing various concentrations of BacSp222 forms: unmodified BacSp222 and suc-K20-BacSp222. After incubation, the culture media were transferred on a fresh plate for further analyses. (A) The viability of the cells was measured using the MTT method. (B) The LDH activity in the medium indicates cell membrane damage in the presence of the various forms of bacteriocin. * p < 0.05.