Table 3.
Lung carcinogenesis models with inflammation.
| Lung Tumor Inducer | Inflammatory or Anti-Inflammatory Substances | Animals | Histopathological Type of Tumors | References |
|---|---|---|---|---|
| DHPN | quartz and dextran sulfate sodium | F344 rats | AD, AC | [13] |
| erythromycin, ampicillin, sho-saiko-to or piroxicam | Wistar rats | AC, SCC, ADSC | [78] | |
| None | Wistar rats | AC, SCC, ADSC | [78] | |
| NNK | quartz | A/J mice | AD, AC | [16] |
| LPS | FVB/NJ mice | AD, AC | [133,136] | |
| flaxseed | A/J mice | AD, AC | [141] | |
| NDMA | quartz | Balb/c mice | AD, AC | [131] |
| BaP | LPS | C57BL/6 | AD, AC | [132] |
| NTCU | LPS | A/J mice | SCC | [81] |
| None | quartz | F344 rats | AD, AC | [7] |
NDMA, N-nitrosodimethylamine; LPS, lipopolysaccharide; AD, adenoma; ADC, adenocarcinoma; ADSC, adenosquamous carcinoma, SCC, squamous cell carcinoma; None, no use of tumor inducer or inflammatory substance.