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. 2021 Jun 10;22(12):6264. doi: 10.3390/ijms22126264

Figure 1.

Figure 1

Implication of nitric oxide (NO) during carcinogenesis. Although NO is relevant for homeostasis, it may influence cell proliferation, metastasis potential, cancer stem cells (CSCs) maintenance and renewal, chemo- and apoptosis resistance, as well as modulating the tumor microenvironment and angiogenesis according to its concentration-, time- and compartment-dependent generation.