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. 2021 Jun 10;22(12):6258. doi: 10.3390/ijms22126258

Figure 4.

Figure 4

Exosome-derived TP53 c.818G > A was integrated into the DNA of normal recipient hepatocytes. THLE-2 cells were incubated with exosomes released from SW480 cells (untreated: EXO CTRL, LPS stimulated: EXO LPS) in the presence of pro-inflammatory cytokines (CK) for 8 days and then for an additional 10 days without exosomes (A). Mutated TP53 was detected by droplet digital PCR on extracted DNA (A) and RNA (B). Data are shown as mean (n = 4) ± SD. * p < 0.05, compared with cells cultured in the absence of cytokines; § p < 0.05, compared with untreated cells.