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Altered glucose and glutamine metabolism in CRC. Dysregulated enzymes are represented with ↑ indicating upregulation. Glucose is uptaken by the cell through GLUT1 transporter and is further metabolized by different enzymatic reactions. Cancer cells are favoring lactate accumulation through upregulating enzymes such as LDH. Detailed information is provided in the text.2PG: 2-phosphoglycerate; PEP: phosphoenolpyruvate; PDH: pyruvate dehydrogenase.
