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. 2021 Jun 11;15:689193. doi: 10.3389/fnbeh.2021.689193

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Copyright © 2021 Plataki, Diskos, Sougklakos, Velissariou, Georgilis, Stavroulaki and Sidiropoulou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of neonatal treatment with MK-801 at p7–14 (A,B) (n = 15) and p11–15 (C,D) (n = 15) compared to the respective saline-treated mice (n = 13 for each saline-treated group) on sociability and social memory. Open bars represent saline-treated mice, while colored bars represent the nMK-801-treated mice. (A) In the sociability test, there was a significant effect of nMK-801 (p7–14) treatment (F_(1,26) = 15.264, p = 0.001), but not effect of sex (F_(1,26) = 3.809, p = 0.061) or sex*treatment interaction (F_(1,26) = 0.013, p = 0.909). (B) In the social memory test, there was a significant effect of sex*treatment interaction (F_(1,26) = 10.303, p = 0.003), but no effect of sex (F_(1,26) = 0.962, p = 0.335) or nMK-801(p11–15) treatment interaction (F_(1,26) = 2.084, p = 0.159). (C) In the sociability test, there was a significant effect of nMK-801 (p11–15) treatment (F_(1,26) = 9.539, p = 0.004), but not effect of sex (F_(1,26) = 0.998, p = 0.324) or sex*treatment interaction (F_(1,26) = 4.103, p = 0.050). (D) In the social memory test here was a significant effect of treatment (F_(1,26) = 22.061, p < 0.001), but not an effect of sex (F_(1,26) = 0.831, p = 0.370) or sex*treatment interaction (F_(1,26) = 4.073, p = 0.052). ***p < 0.001.