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. 2021 Jun 11;15:689193. doi: 10.3389/fnbeh.2021.689193

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Copyright © 2021 Plataki, Diskos, Sougklakos, Velissariou, Georgilis, Stavroulaki and Sidiropoulou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of neonatal treatment with MK-801 at p7–14 (A) (n = 15) and p11–15 (B) (n = 15) compared to the respective saline-treated mice (n = 13 for each saline-treated group) on contextual fear memory and extinction. Open bars represent saline-treated mice, while colored bars represent the nMK-801-treated mice. (A) Repeated measures ANOVA analysis revealed day*treatment interaction (F_(1,26) = 7.552, p = 0.014). Per-day two-way ANOVA analyses showed that there was an effect of sex on day 1, no other effects on day 2–5 and a treatment effect on day 6 (F_(1,26) = 18.412, p = 0.001), but not an effect of sex or sex*treatment interaction (p7–14 model). (B) Repeated measures ANOVA analysis revealed day*treatment interaction (F_(1,26) = 6.552, p = 0.016). Per-day two-way ANOVA analyses showed that there was an effect of sex on day1, no other effects on day 2–5 and a treatment effect on day 6 (F_(1,26) = 15.334, p = 0.001), but not an effect of sex or sex*treatment interaction (p11–15 model). *p < 0.05.