Chronic effects of twice-daily oral administration of hot-water extract of A. arabica bark on (A) glucose tolerance, (B) plasma insulin and (C) plasma DPP-IV on Day 6 and (D) blood glucose, (E) plasma insulin, (F) plasma DPP-IV, (G) pancreas weight and (H) pancreatic insulin content on Day 9 in high-fat-fed rats. Parameters were measured after treatment for 6 or 9 days with twice-daily oral administration of hot-water extract of A. arabica bark (250 mg/5 mL/kg body weight). Values are the mean ± SEM with n = 8 (~32 per group for pancreatic insulin content). * p < 0.05, ** p < 0.01 and *** p < 0.001 compared to lean control. Δ
p < 0.05, ΔΔ
p < 0.01 and ΔΔΔ
p < 0.001 compared to high-fat-fed control at corresponding time points.