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. 2021 Jun 11;10(6):1190. doi: 10.3390/plants10061190

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of 9-day twice-daily oral administration of hot-water extract of A. arabica bark on islet morphology in high-fat-fed rats. Representative images of (A) lean control, (B) high-fat-fed control and (C) high-fat-fed plus hot-water extract of A. arabica (250 mg/5 mL/kg) in rats showing insulin in red, glucagon in green and DAPI in blue, (D) islet area, (E) alpha-cell area, (F) beta-cell area, (G) islet size distribution, (H) alpha-cell percentage, (I) beta-cell percentage and (J) number of islets (per mm²), respectively. Values are the mean ± SEM for n = 8 (~50 islets per group). * p < 0.05, ** p < 0.01 and *** p < 0.001 compared to lean control. ^Δ p < 0.05 compared to high fat fed alone (control).