Table 1.

The combination index values (CI < 0.8: synergism; 0.8 < CI < 1.2: additive effect; and CI > 1.2: antagonism) and combined cytotoxic effects of ZEN with cytotoxic concentrations of ZELs, ZAN, ZALs, and AOH.

20 µM ZEN +	CI Value	Combined Cytotoxic Effect
10 µM α-ZEL	0.57	Synergism	++
30 µM α-ZEL	0.81	Additive effect	±
10 µM β-ZEL	0.64	Synergism	+
30 µM β-ZEL	1.07	Additive effect	±
10 µM ZAN	0.55	Synergism	++
30 µM ZAN	0.77	Synergism	+
10 µM α-ZAL	0.52	Synergism	++
30 µM α-ZAL	0.78	Synergism	+
10 µM β-ZAL	0.51	Synergism	++
30 µM β-ZAL	0.72	Synergism	+
10 µM AOH	0.73	Synergism	+
30 µM AOH	0.50	Synergism	++

ZEN, zearalenone; α-ZEL, α-zearalenol; β-ZEL, β-zearalenol; ZAN, zearalanone; α-ZAL, α-zearalanol; β-ZAL, β-zearalanol; AOH, alternariol; CI < 0.60: ++; 0.60 < CI < 0.80: +; and 0.80 < CI < 1.20: ±.