Table 2.
Classification of thalassemia (adapted from [72]).
| Classification | Types | Transfusions | Explanation | |
|---|---|---|---|---|
| Thalassemia minor | α-thalassemia trait β-thalassemia trait Homozygous HbE/C HbE or C trait |
Seldom required | ||
| Thalassemia intermedia | β-thalassemia intermedia HbC/β-thalassemia |
Mild HbE/β-thalassemia, HbH with β-thalassemia trait | Occasionally required | Non-transfusion-dependent thalassemia: (NTDT) |
| Deletional HbH, nondeletional HbH, moderate HbE/β-thalassemia EF Bart’s disease, AE Bart’s disease |
Intermittently required | |||
| Thalassemia major | Nondeletional HbH Survived Hb Bart’s hydrops β-thalassemia major Severe HbE/β-thalassemia |
Regular, lifelong transfusion required | Transfusion-dependent thalassemia (TDT) | |