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. 2021 Jun 11;11(6):775. doi: 10.3390/brainsci11060775

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Pharmacokinetic models: (a) extended Tofts model, (b) Patlak model. $K^{T r a n s}$ , volume transfer constant; $v_{e}$ , extravascular extracellular space volume fraction; $v_{p}$ , blood plasma volume fraction.